Tiny selenium particles could have a therapeutic effect on ischemic brain strokes by promoting the recovery of brain damage. Pharmacologists, including Alireza Mashaghi from the Leiden Academic Centre for Drug Research discovered that selenium nanoparticles inhibit molecular mechanisms that are responsible for the loss of brain cells after a stroke. The results were published in Nature Scientific Reports in April.
Nanoparticles against strokes
An ischemic stroke happens when a supplying blood vessel to the brain is narrowed or obstructed. As a result, the brain gets too little blood. “This lack of blood can lead to brain tissue damage due to cellular toxicity, inflammation and cell death,” Mashaghi explains. “This will, in turn, lead to brain dysfunction and neurological complaints such as numbness, vision problems, dizziness and severed headache.” Ischemic stroke accounts for 87% of all strokes and is a significant cause of death. “So far, no neuroprotective agents have been shown to produce any measurable improvement in health in cerebral stroke cases. Our results now demonstrated that selenium nanoparticles inhibit molecular mechanisms that are responsible for the loss of brain cells after a stroke.”
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