Scientists have captured new images of a calcium-shuttling molecule that has been linked to aggressive cancers. The three-dimensional structure could help researchers develop novel therapies and diagnostic tools for diseases that are caused by a malfunction in calcium adsorption.
Alexander Sobolevsky’s lab at Columbia University Medical Center is studying a family of proteins called “Transient receptor potential (TRP)” channels. These proteins line surfaces inside the body, such as the intestine, and form pores that help calcium cross a dense barrier of lipid and protein called the membrane to reach the interior of the cell.
“Scientists have found that a TRP channel variant, called TRPV6, is present in excess amounts in the tumor cells of some cancer patients,” says senior author Alexander Sobolevsky, PhD, who is an assistant professor in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center. “And patients who have higher quantities of TRPV6 seem to have a more aggressive form of the disease.”
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