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Jul 31, 2021

George Church on Gene Therapies and Longevity

Posted by in categories: biotech/medical, genetics, life extension

“Balancing that, I clearly state that my goal is not longevity, not even modest longevity. It’s just reversal of diseases of aging, which really is classic medicine. Q: Which takes me to the next question: do we even know how to aim at life extension? I don’t think we do. I think if we get serious aging reversal, it’s something that we can continue to improve on, just like we improved on transportation from the first wheel to rocket ships,” I’ll be honest, I disagree as we have some improvement in humans indicated from TRIM and TAME and plasma filtering. Church’s work is very important though.


Professor of Genetics at Harvard Medical School and one of the most prominent geroscientists, George Church works on gene therapies that can potentially reverse age-related diseases. We had the opportunity to interview this prolific researcher and entrepreneur, who is involved in dozens of startups on topics ranging from the current state of gene therapy to his recent attempt to auction off his genome, one of the first sequenced human genomes in the world, as an NFT.

What have been the successes and the failures of gene therapy in recent years? What do you expect to happen in the next few years?

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Jul 31, 2021

Stem Cell Scientists Explore the Latent Regenerative Potential of the Inner Ear

Posted by in categories: bioengineering, biotech/medical, genetics, life extension

“Our study raises the possibility of using therapeutic drugs, gene editing, or other strategies to make epigenetic modifications that tap into the latent regenerative capacity of inner ear cells as a way to restore hearing,” said Segil. “Similar epigenetic modifications may also prove useful in other non-regenerating tissues, such as the retina, kidney, lung, and heart.”


Scientists from the USC Stem Cell laboratory of Neil Segil have identified a natural barrier to the regeneration of the inner ear’s sensory cells, which are lost in hearing and balance disorders. Overcoming this barrier may be a first step in returning inner ear cells to a newborn-like state that’s primed for regeneration, as described in a new study published in Developmental Cell.

“Permanent hearing loss affects more than 60 percent of the population that reaches retirement age,” said Segil, who is a Professor in the Department of Stem Cell Biology and Regenerative Medicine, and the USC Tina and Rick Caruso Department of Otolaryngology – Head and Neck Surgery. “Our study suggests new gene engineering approaches that could be used to channel some of the same regenerative capability present in embryonic inner ear cells.”

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Jul 31, 2021

I’m sorry Dave I’m afraid I invented that: Australian court finds AI systems can be recognised under patent law

Posted by in categories: food, law, robotics/AI

The applications claimed Dabus, which is made up of artificial neural networks, invented an emergency warning light and a type of food container, among other inventions.

Several countries, including Australia, had rejected the applications, stating a human must be named the inventor. The decision by the Australian deputy commissioner of patents in February this year found that although “inventor” was not defined in the Patents Act when it was written in 1991 it would have been understood to mean natural persons – with machines being tools that could be used by inventors.

But in a federal court judgment on Friday, justice Jonathan Beach overturned the decision, and sent the matter back to the commission for reconsideration.

Jul 31, 2021

DALL·E: Creating Images from Text

Posted by in category: robotics/AI

We’ve trained a neural network called DALL·E that creates images from text captions for a wide range of concepts expressible in natural language.

Jul 31, 2021

Grand AI consortium formed in S. Korea to develop artificial brain with high-performance computational capability

Posted by in category: robotics/AI

[Gettyimages Bank]

Jul 31, 2021

GPR-1 sorts balls

Posted by in category: futurism

GPR-1 under pilot control doing some basic sortation.

Jul 31, 2021

Simulating worlds on the GPU

Posted by in category: computing

This post delves into the implementation of my procedural earth simulation, written entirely in GLSL fragment shaders. It simulates the complete history of an earth-like planet in a few minutes, with the simulation updating at 60 frames per second.

Jul 31, 2021

Acoustic tweezers can pick up objects without physical contact

Posted by in categories: biological, chemistry, particle physics

Researchers from Tokyo Metropolitan University have developed a new technology which allows non-contact manipulation of small objects using sound waves. They used a hemispherical array of ultrasound transducers to generate a 3D acoustic field that stably trapped and lifted a small polystyrene ball from a reflective surface. Their technique employs a method similar to laser trapping in biology, but adaptable to a wider range of particle sizes and materials.

The ability to move objects without touching them might sound like magic, but in the world of biology and chemistry, technology known as has been helping scientists use light to move microscopic objects around for many years. In fact, half of the 2018 Nobel Prize for Physics, awarded to Arthur Ashkin (1922–2020) was in recognition of the remarkable achievements of this technology. But the use of laser light is not without its failings, particularly the limits placed on the properties of the objects which can be moved.

Enter acoustic trapping, an alternative that uses sound instead of optical waves. Sound waves may be applied to a wider range of sizes and materials, and successful manipulation is now possible for millimeter-sized particles. Though they haven’t been around for as long as their optical counterparts, acoustic levitation and manipulation show exceptional promise for both lab settings and beyond. But the that need to be surmounted are considerable. In particular, it is not easy to individually and accurately control vast arrays of ultrasound transducers in real time, or to get the right sound fields to lift objects far from the transducers themselves, particularly near surfaces that reflect .

Jul 31, 2021

Dietary CD38 Inhibitors: Are They Correlated With Biological Age?

Posted by in categories: biological, food, life extension

Apigenin, quercetin, luteolin data: USDA Database for the Flavonoid.
Content of Selected Foods.
https://www.ars.usda.gov/arsuserfiles/80400525/data/flav/flav_r03-1.pdf.

Kuromanin data: http://phenol-explorer.eu/contents/polyphenol/9

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Jul 31, 2021

Pupil size surprisingly linked to differences in intelligence

Posted by in category: neuroscience

Maybe eyes really are windows into the soul — or at least into the brain, as a new study finds.